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In a prospective study of 8 children with ASD, 75 µg/kg mB12 SC two times per week for one month was given along with folinic acid (800 µg twice a day orally) and betaine (1000 mg twice a day orally)

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The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks