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Metabolic peptides: emerging research MOTS-C Evidence level : Preclinical research, emerging human data Key findings : Metabolic effects (Lee et al., 2015): Improves insulin sensitivity Enhances glucose metabolism Mitochondrial-derived peptide Exercise mimetic (Reynolds et al., 2021): Enhances metabolic response to exercise Improves physical performance Increases fat oxidation Human trials : Early phase but promising results

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Statistical analyses were performed using either an un-paired t -test assuming equal variance, one-, or two-way ANOVA, as appropriate, and are specifically indicated on each figure legend

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