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Chronic inflammation is a hallmark of cartilage degradation in osteoarthritis (OA), and thus, reducing copper concentrations in OA-affected joints may represent a significant strategy for anti-inflammatory intervention and attenuation of OA-related damage.Furthermore, optimal concentrations of copper ions facilitate the polarization of macrophages towards an anti-inflammatory phenotype, thereby mitigating the progression of synovial inflammation during remission (Xu X