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Acute and chronic use of cannabis is associated with different harmful effects on central nervous system and peripheral system including hyperemesis syndrome, impaired coordination and performance, anxiety, suicidal/tendencies, psychotic symptoms and mood disorders, cannabis withdrawal symptoms, exacerbation of psychotic disorders, neurocognitive impairment, cardiovascular, neurological, respiratory, cerebrovascular, peripheral vascular diseases (Thomas et al., 2014

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Moreover, dietary CGA can regulate gut microbiota in the HUA mouse model