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In men, HCG is employed to stimulate testosterone production and spermatogenesis in hypogonadotropic hypogonadism (secondary hypogonadism due to pituitary deficiency)

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With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)