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In vitro experiments showed FOXO4-DRI to be more potent against senescent cells in which SASP was transiently boosted by recombinant IL1α/β or LPS, whereas an IL1 receptor antagonist or the general anti-inflammatory drug Cortisol reduced its potency (Fig

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It is a great therapeutic strategy to increase NPCs by adding exogenous stem cells to degenerative discs (Vadalà et al., 2016