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Whereas Parkinson’s is marked by abnormal clumps of the protein alpha-synuclein in the brain, progressive supranuclear palsy is characterized by toxic clumps of another protein called tau

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Apart from poor drug utilization (only part of the applied drug dose is absorbed by the skin), the US Food & Drug Administration (FDA) and the European Medicines Agency (EMA) have encouraged the development of alternative approaches for the assessment of cutaneous bioavailability and characterization of topical formulations and their transformation into a residual film upon application to the skin [208,209]