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Figure 8 3.5 Chronic fatigue syndrome (CFS) A growing body of clinical evidence shows that the gut microbiota plays a critical role in CFS, with consistently observed reductions in butyrate-producing bacteria and enrichment of Enterobacteriaceae , together with frequent depletion of anti-inflammatory taxa such as Faecalibacterium (König et al., 2021

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Monoclonal antibodies targeting the conserved PG portion (N-acetyl-L-isoglutamine) have been developed, which can specifically bind to PG ( C